Synthroid Levothyroxine Sodium: Side Effects, Uses, Dosage, Interactions, Warnings

Measure and evaluate unbound (free) hormone and/or determine the free-T4 index (FT4I) in this circumstance. Pregnancy, infectious hepatitis, estrogens, estrogen-containing oral contraceptives, and acute intermittent porphyria increase TBG concentration. Nephrosis, severe hypoproteinemia, severe liver disease, acromegaly, androgens, and corticosteroids decrease TBG concentration. Familial hyper- or hypo-thyroxine binding globulinemias have been described, with the incidence of TBG deficiency approximating 1 in 9000. Stop biotin and biotin-containing supplements for at least 2 days before assessing TSH and/or T4 levels see Drug Interactions (7.10).

The recommended starting daily dosage of SYNTHROID in adults with primary, secondary, or tertiary hypothyroidism is based on age and comorbid cardiac conditions, as described in Table 1. For patients at risk of atrial fibrillation or patients with underlying cardiac disease, start with a lower dosage and titrate the dosage more slowly to avoid exacerbation of cardiac symptoms. Dosage titration is based on serum TSH or free-T4 see Important Considerations For Dosing. Dosage titration is based on serum TSH or free-T4 see Dosage and Administration (2.2). For secondary or tertiary hypothyroidism, serum TSH is not a reliable measure of SYNTHROID dosage adequacy and should not be used to monitor therapy.

off your first Thyroid Test

If your child is unable to swallow the tablet, you may crush and mix it in 1 to 2 teaspoons (5 to 10 milliliters) of water. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Synthroid only for the indication prescribed. Euthyrox (levothyroxine) is used to treat hypothyroidism and to treat or prevent goiter. Armour Thyroid is used for hashimoto’s disease, hypothyroidism, after thyroid removal, thyroid … This is not a complete list of side effects and others may occur.

• Since postpartum TSH levels are similar to preconception values, the SYNTHROID dosage should return to the pre-pregnancy dose immediately after delivery see Dosage and Administration (2.3).
• By managing both hypothyroidism and TMJ disorder effectively, you can find relief and improve your overall quality of life.
• Seeking professional guidance is crucial for accurate diagnosis and appropriate treatment.
• Published studies report that levothyroxine is present in human milk following the administration of oral levothyroxine.
• If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. Synthroid should not be used to treat obesity or weight problems. Dangerous side effects or death can occur from the misuse of levothyroxine, especially if you are taking any other weight-loss medications or appetite suppressants. Synthroid is a prescription medicine used to treat hypothyroidism (low thyroid hormone). Levothyroxine is given when your thyroid does not produce enough of this hormone on its own. If you have been diagnosed with hypothyroidism and are experiencing jaw pain, stiffness, or other TMJ-related symptoms, it is worth exploring a potential connection between the two conditions.

How is TMJ disorder treated?

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. This includes prescription and over-the-counter medicines, vitamins, and herbal products.

• Your doctor may want you or your child to gradually reduce the amount you are using before stopping completely.
• Notify your doctor if you experience serious side effects of Synthroid including rapid heartbeat, fluttering in your chest, or chest pain.
• Thyroid hormones are also metabolized via conjugation with glucuronides and sulfates and excreted directly into the bile and gut where they undergo enterohepatic recirculation.
• This hormone regulates the body’s metabolism, growth, and development.
• Adequate levothyroxine treatment during lactation may normalize milk production in hypothyroid lactating mothers with low milk supply.

Concurrent use of tyrosine-kinase inhibitors such as imatinib may cause hypothyroidism. Monitor serum free-T4 levels and synthroid reduction maintain in the upper half of the normal range in these patients. Levothyroxine should not be used for the treatment of obesity or for the purpose of losing weight. If taken in large amounts, levothyroxine may cause serious unwanted effects. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

CLINICAL PHARMACOLOGY

Protein-bound thyroid hormones exist in reverse equilibrium with small amounts of free hormone. Many drugs and physiologic conditions affect the binding of thyroid hormones to serum proteins see DRUG INTERACTIONS. Thyroid hormones do not readily cross the placental barrier see Use In Specific Populations. Rapid restoration of normal serum T4 concentrations is essential for preventing the adverse effects of congenital hypothyroidism on cognitive development as well as on overall physical growth and maturation. Therefore, initiate SYNTHROID therapy immediately upon diagnosis.

Consider the potential for food or drug interactions and adjust the administration or dosage of SYNTHROID as needed see Dosage and Administration (2.1), Drug Interactions (7.1), and Clinical Pharmacology (12.3). Do not administer in foods that decrease absorption of SYNTHROID, such as soybean-based infant formula see Drug Interactions (7.9). Many other medicines can be affected by your thyroid hormone levels. Certain other medicines may also increase or decrease the effects of Synthroid.

In addition, many drugs and foods affect T4 absorption see DRUG INTERACTIONS. In addition, many drugs and foods affect T4 absorption see Drug Interactions (7). The recommended starting daily dosage of SYNTHROID in pediatric patients with primary, secondary, or tertiary hypothyroidism is based on body weight and changes with age as described in Table 2. Titrate the dosage (every 2 weeks) as needed based on serum TSH or free- T4 until the patient is euthyroid see Important Considerations For Dosing. Titrate the dosage (every 2 weeks) as needed based on serum TSH or free-T4 until the patient is euthyroid see Dosage and Administration (2.2). In adult patients with primary hypothyroidism, monitor serum TSH levels after an interval of 6 to 8 weeks after any change in dosage.

Although not all of these side effects may occur, if they do occur they may need medical attention. Make sure any doctor or dentist who treats you knows that you or your child are using this medicine. You or your child may need to stop using this medicine several days before having surgery or medical tests. Women who are post-menopausal or who use this medicine for a long time may have some bone loss, which could lead to osteoporosis. Talk with your doctor if you have questions or concerns about this. If you think you have become pregnant while using this medicine, tell your doctor right away.